GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | multiple interactions | EXP | | 6480464 | CTD | Chloroquine promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein] | PMID:27658547 PMID:34374793 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Chloroquine results in increased cleavage of PARP1 protein | PMID:28906492 PMID:30338810 PMID:35022897 | Parp1 | increases cleavage | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Chloroquine results in increased cleavage of PARP1 protein | PMID:31310755 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein; [Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Arsenic Trioxide promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [SC-66 compound results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [sodium arsenite results in increased activity of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]] | PMID:28906492 PMID:30025493 PMID:30338810 PMID:30985881 PMID:32190974 PMID:34826546 PMID:35022897 PMID:36958258 PMID:37741534 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] | PMID:29111403 | | ||||||||||||||||||||||
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