GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [7-ketocholesterol results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Gentamicins results in increased activity of PARP1 protein] | PMID:11470263 PMID:18703135 PMID:22714038 PMID:23405080 PMID:24634002 PMID:25845326 PMID:27658547 | Parp1 | decreases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Acetylcysteine results in decreased expression of PARP1 protein modified form | PMID:31433961 | Parp1 | increases cleavage | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Acetylcysteine results in increased cleavage of PARP1 protein | PMID:15375156 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [Acetylcysteine affects the abundance of Reactive Oxygen Species] inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; [Acetylcysteine results in increased susceptibility to 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] which results in increased cleavage of PARP1 protein; [Glucose deficiency co-treated with Acetylcysteine] results in increased cleavage of PARP1 protein; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [2-hydroxy-3',5,5'-trimethoxychalcone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [4-chromone analog results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [5-methylselenylmethyl-2'-deoxyuridine results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [5-phenylselenylmethyl-2'-deoxyuridine results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Arsenic Trioxide co-treated with phytosphingosine] results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[cholix toxin, Vibrio cholerae co-treated with TNF protein] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[CSC-3436 co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[S100A11 mutant form results in increased susceptibility to Cisplatin] which results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with TNF protein] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with gingerol] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[TNFSF10 protein co-treated with tanshinone] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Verapamil co-treated with gambogic acid] results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [ABBV-744 results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in increased expression of PARP1 mRNA]; Acetylcysteine inhibits the reaction [Acrylamide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Acrylonitrile results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Cisplatin results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased cleavage of and results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [chloropicrin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cisplatin promotes the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [divinyl sulfone analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [frenolicin B results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [isoliensinine results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [manumycin results in increased cleavage of PARP1]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Morpholines analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [N-methylisoindigotin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [nickel chloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [osimertinib results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [pendulone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Plant Extracts results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [salvin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [scutebarbatine A results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [shikonin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [shogaol promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; Acetylcysteine inhibits the reaction [shogaol results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [sinularin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [thymoquinone results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [TNFSF10 protein results in increased expression of PARP1 protein modified form]; Acetylcysteine inhibits the reaction [tomentosin results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [wedelolactone results in increased cleavage of PARP1 protein]; Acetylcysteine promotes the reaction [dihydromyricetin results in increased cleavage of PARP1 protein]; Acetylcysteine results in decreased susceptibility to [1-(3',4',5'-trimethoxyphenyl)-3-(3'',4''-dimethoxy-2'-hydroxyphenyl)propane results in increased cleavage of PARP1 protein] | PMID:14660655 PMID:15496615 PMID:17237268 PMID:17309078 PMID:18281123 PMID:18384088 PMID:18703135 PMID:19409983 PMID:19536524 PMID:19679660 PMID:20674558 PMID:20981856 PMID:21031461 PMID:22002103 PMID:22172632 PMID:22578287 PMID:22733624 PMID:22922937 PMID:23082001 PMID:23711929 PMID:24036456 PMID:24100277 PMID:24373880 PMID:24463199 PMID:24875536 PMID:25034532 PMID:25246272 PMID:25619640 PMID:25824409 PMID:25939952 PMID:25940438 PMID:25972196 PMID:26203587 PMID:26219228 PMID:26887594 PMID:27106530 PMID:27539140 PMID:27634458 PMID:28087840 PMID:28237877 PMID:28548367 PMID:28918123 PMID:29111459 PMID:29479036 PMID:29774349 PMID:29800641 PMID:29944906 PMID:30256521 PMID:30408460 PMID:30661989 PMID:30871965 PMID:30917517 PMID:31157515 PMID:31313457 PMID:31433961 PMID:31884112 PMID:32662599 PMID:33002460 PMID:33971260 PMID:34599545 PMID:34627931 PMID:35288263 PMID:35396826 PMID:36070022 PMID:37072049 PMID:37769529 PMID:38042493 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [[Mercuric Chloride co-treated with prolinedithiocarbamate] results in increased degradation of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased activity of PARP1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [cadmium sulfate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Diethylhexyl Phthalate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of PARP1 protein]; Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased cleavage of PARP1 protein] | PMID:14687664 PMID:21565247 PMID:22909951 PMID:24157283 PMID:24614525 PMID:29111403 PMID:29248572 PMID:30796935 PMID:31330229 PMID:31408635 | | ||||||||||||||||||||||
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