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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageEXP 6480464CTDGenistein results in increased cleavage of PARP1 proteinPMID:24884420
Parp1multiple interactionsEXP 6480464CTDGenistein inhibits the reaction [bisphenol A results in decreased cleavage of PARP1 protein]PMID:24884420
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDGenistein results in increased cleavage of PARP1 proteinPMID:12791511 PMID:21078540
Parp1increases cleavageISOParp1 (Mus musculus)6480464CTDGenistein results in increased cleavage of PARP1 proteinPMID:21078540 PMID:25756279
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[Fluorouracil co-treated with Genistein] results in increased cleavage of PARP1 protein; [Genistein co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 proteinPMID:15896711 PMID:21078540
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTD[Genistein co-treated with arsenic trioxide] results in increased cleavage of PARP1 proteinPMID:21078540
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