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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:24814
Term: indole-3-methanol
Definition: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Chemical ID: MESH:C016517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases cleavageISOParp1 (Mus musculus)6480464CTDindole-3-carbinol results in increased cleavage of PARP1 proteinPMID:29775573
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTDindole-3-carbinol promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]; indole-3-carbinol results in decreased expression of and results in increased cleavage of PARP1 proteinPMID:15811958 PMID:29992829
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