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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:16171
Term: NMN zwitterion
Definition: A nicotinamide mononucleotide that has formula C11H15N2O8P.
Chemical ID: MESH:D009537
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1affects abundanceISOPARP1 (Homo sapiens)6480464CTDPARP1 protein affects the abundance of Nicotinamide MononucleotidePMID:19426698
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTD[Nicotinamide Mononucleotide co-treated with Cisplatin] results in decreased expression of PARP1 protein; Nicotinamide Mononucleotide inhibits the reaction [Zearalenone results in increased expression of PARP1 mRNA]PMID:34089817 PMID:38159578
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