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GENE - TERM ANNOTATION REPORT

RGD ID: 18911540
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Stat4
Name: signal transducer and activator of transcription 4
Acc ID: DOID:12236
Term: primary biliary cholangitis
Definition: A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Primary_biliary_cirrhosis "DO" "DO", http://www.merckmanuals.com/professional/hepatic_and_biliary_disorders/fibrosis_and_cirrhosis/primary_biliary_cirrhosis_pbc.html?qt=primary%20biliary%20cirrhosis&alt=sh "DO" "DO", https://www.mayoclinic.org/diseases-conditions/primary-biliary-cholangitis-pbc/symptoms-causes/syc-20376874 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat4no_associationISOSTAT4 (Homo sapiens)9068941RGDDNA:SNPs:3'utr: (rs7574865, rs8179673, rs10181656) (human)PMID:24648611 REF_RGD_ID:25671415
Stat4susceptibilityISOSTAT4 (Homo sapiens)9068941RGDassociated with Crohn���s disease; DNA:SNP:intron: (rs7574865) (human)PMID:26084578 REF_RGD_ID:25671421
Stat4susceptibilityISOSTAT4 (Homo sapiens)9068941RGDDNA:SNP: intron: (rs7574865) (human)PMID:28395724 REF_RGD_ID:25671416
Stat4susceptibilityISOSTAT4 (Homo sapiens)9068941RGDDNA:SNPs, haplotypes:multiple PMID:24648611 REF_RGD_ID:25671415
Stat4 ISOSTAT4 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:21399635
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