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GENE - TERM ANNOTATION REPORT

RGD ID: 18902400
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Pon1
Name: paraoxonase 1
Acc ID: DOID:1936
Term: atherosclerosis
Definition: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA. (DO)
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pon1 ISOPON1 (Homo sapiens)9068941RGDmRNA:altered expression::human transgene expression in ApoE-KO mice was protectivePMID:20182519 REF_RGD_ID:5509927
Pon1susceptibilityISOPON1 (Homo sapiens)9068941RGDassociated with Beta-Thalassemia;protein:decreased activity:serum (human)PMID:21427447 REF_RGD_ID:11552582
Pon1treatmentISOPon1 (Mus musculus)9068941RGD PMID:16043712 PMID:20660283 REF_RGD_ID:8547562 REF_RGD_ID:8547574
Pon1 ISOPON1 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanism|therapeuticPMID:16216721 PMID:16229851 PMID:16331452 PMID:19371607 PMID:21629682 PMID:26241956
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