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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1619652
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a6b
Name: UDP glucuronosyltransferase 1 family, polypeptide A6B
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a6bdecreases methylationISOUGT1A6 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased methylation of UGT1A6 genePMID:27153756
Ugt1a6bincreases expressionISOUGT1A6 (Homo sapiens)6480464CTDAflatoxin B1 results in increased expression of UGT1A6 mRNAPMID:27153756
Ugt1a6bincreases expressionISOUgt1a6 (Rattus norvegicus)6480464CTDAflatoxin B1 results in increased expression of UGT1A6 mRNAPMID:23630614 PMID:25378103 PMID:33354967
Ugt1a6bmultiple interactionsISOUGT1A6 (Homo sapiens)6480464CTD[Aflatoxin B1 co-treated with Oxygen deficiency] results in decreased expression of UGT1A6 mRNAPMID:33811995
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