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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604940
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC27A1
Name: solute carrier family 27 member 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC27A1decreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of SLC27A1 mRNAPMID:32790152
SLC27A1increases expressionISOSlc27a1 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of FATP1 mRNA; perfluorooctanoic acid results in increased expression of SLC27A1 mRNAPMID:17681415 PMID:18467677 PMID:20936131 PMID:23626681 PMID:30657992 PMID:30711707 PMID:38182912
SLC27A1multiple interactionsISOSlc27a1 (Mus musculus)6480464CTDDietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of SLC27A1 mRNA]; PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of SLC27A1 mRNA]PMID:18467677 PMID:20936131 PMID:23626681
SLC27A1multiple interactionsISOSlc27a1 (Rattus norvegicus)6480464CTD[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of SLC27A1 mRNAPMID:35163327
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