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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1598310
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rrm2
Name: ribonucleotide reductase regulatory subunit M2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rrm2decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of RRM2 mRNAPMID:32109520
Rrm2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of RRM2 mRNAPMID:34747641
Rrm2affects expressionISORrm2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of RRM2 mRNAPMID:21570461 PMID:26377647
Rrm2affects expressionISORRM2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of RRM2 mRNAPMID:22574217
Rrm2decreases expressionISORrm2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of RRM2 mRNAPMID:19770486 PMID:25270620
Rrm2decreases expressionISORRM2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of RRM2 mRNAPMID:21802500
Rrm2increases expressionISORrm2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of RRM2 mRNAPMID:15667827 PMID:19465110
Rrm2increases expressionISORRM2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of RRM2 mRNAPMID:20106945
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