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GENE - TERM ANNOTATION REPORT

RGD ID: 1593282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: RT1-Db1
Name: RT1 class II, locus Db1
Acc ID: DOID:9182
Term: pemphigus
Definition: An autoimmune disease of skin and connective tissue that is characterized by blistering of the outer layer of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals), causing lesions and blisters that are easily ruptured. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Pemphigus "DO" "DO", https://medlineplus.gov/pemphigus.html "DO" "DO", https://rarediseases.org/rare-diseases/pemphigus/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RT1-Db1 ISOHLA-DRB1 (Homo sapiens)5147619RGDDNA:polymorphisms (human) 
RT1-Db1susceptibilityISOHLA-DRB1 (Homo sapiens)9068941RGDDNA:polymorphism:cds:HLA-DRB1*0403, *0406, *1401, *1405, *1406 (human)PMID:9347787 REF_RGD_ID:40818304
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