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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1592345
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mt2A
Name: metallothionein 2A
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mt2Aincreases expressionISOMT2A (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of MT2A mRNAPMID:20858459
Mt2Aincreases response to substanceISOMt2 (Mus musculus)6480464CTDMT2 results in increased susceptibility to Tetradecanoylphorbol AcetatePMID:9506445
Mt2Amultiple interactionsISOMT2A (Homo sapiens)6480464CTD[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MT2A mRNA; BAG1 protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MT2A mRNA]PMID:18958680 PMID:20858459
Mt2Amultiple interactionsISOMt2 (Mus musculus)6480464CTD[Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of MT2 mRNAPMID:31904401
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