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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1588588
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tbk1
Name: TANK-binding kinase 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tbk1increases phosphorylationISOTbk1 (Mus musculus)6480464CTDParaquat results in increased phosphorylation of TBK1 proteinPMID:32763286
Tbk1multiple interactionsISOTbk1 (Mus musculus)6480464CTDamlexanox inhibits the reaction [Paraquat results in increased phosphorylation of TBK1 protein]PMID:32763286
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