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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586165
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kmt2a
Name: lysine methyltransferase 2A
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kmt2aincreases cleavageISOKMT2A (Homo sapiens)6480464CTDEtoposide results in increased cleavage of KMT2A genePMID:24086652
Kmt2aincreases mutagenesisISOKMT2A (Homo sapiens)6480464CTDEtoposide results in increased mutagenesis of KMT2A genePMID:28624474
Kmt2aincreases response to substanceISOKMT2A (Homo sapiens)6480464CTDKMT2A gene mutant form results in increased susceptibility to EtoposidePMID:14712291
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