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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586156
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Top2b
Name: DNA topoisomerase II beta
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2baffects response to substanceISOTop2b (Mus musculus)6480464CTDTOP2B protein affects the susceptibility to EtoposidePMID:17875725
Top2bdecreases activityISOTOP2B (Homo sapiens)6480464CTDEtoposide results in decreased activity of TOP2B proteinPMID:26198043 PMID:27422292
Top2bdecreases expressionISOTop2b (Mus musculus)6480464CTDEtoposide results in decreased expression of TOP2B proteinPMID:10856430
Top2bdecreases response to substanceISOTOP2B (Homo sapiens)6480464CTDTOP2B protein mutant form results in decreased susceptibility to EtoposidePMID:16239602
Top2bincreases response to substanceISOTOP2B (Homo sapiens)6480464CTDTOP2B protein mutant form results in increased susceptibility to EtoposidePMID:15322234
Top2bmultiple interactionsISOTop2b (Mus musculus)6480464CTDTOP2B protein affects the reaction [Etoposide results in increased expression of H2AX protein]PMID:17875725
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