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Gene: Top2b (topoisomerase (DNA) II beta) Mus musculus
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Symbol: Top2b
Name: topoisomerase (DNA) II beta
Description: Predicted to have several functions, including enzyme binding activity; protein C-terminus binding activity; and protein heterodimerization activity. Involved in axonogenesis; forebrain development; and neuron migration. Localizes to the nucleus. Predicted to colocalize with the heterochromatin. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human TOP2B (DNA topoisomerase II beta); PARTICIPATES IN doxorubicin pharmacodynamics pathway; doxorubicin response pathway; etoposide pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: D230016L12Rik; DNA topoisomerase 2-beta; DNA topoisomerase II, beta isozyme; Top-2
Orthologs:
Homo sapiens (human) : TOP2B (DNA topoisomerase II beta)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Top2b (DNA topoisomerase II beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Top2b (DNA topoisomerase II beta)
Pan paniscus (bonobo/pygmy chimpanzee) : TOP2B (DNA topoisomerase II beta)
Canis lupus familiaris (dog) : TOP2B (DNA topoisomerase II beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Top2b (DNA topoisomerase II beta)
Sus scrofa (pig) : TOP2B (DNA topoisomerase II beta)
Chlorocebus sabaeus (green monkey) : TOP2B (DNA topoisomerase II beta)
Heterocephalus glaber (naked mole-rat) : Top2b (DNA topoisomerase II beta)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1416,365,179 - 16,435,462 (+)Ensembl
GRCm381416,365,206 - 16,430,787 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371417,197,720 - 17,263,301 (+)NCBIGRCm37mm9NCBIm37
MGSCv361415,158,473 - 15,224,054 (+)NCBImm8
Celera1412,058,636 - 12,125,106 (+)NCBICelera
Cytogenetic Map14 A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Top2b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557448
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.