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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558600
Species: Mus musculus
RGD Object: Gene
Symbol: Ern1
Name: endoplasmic reticulum to nucleus signalling 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ern1multiple interactionsEXP 6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of ERN1 protein; aucubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of ERN1 protein]PMID:35961541
Ern1increases expressionISOErn1 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of ERN1 protein modified formPMID:20399799
Ern1multiple interactionsISOErn1 (Rattus norvegicus)6480464CTD4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of ERN1 protein modified form]; [Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ERN1 protein; Chlorogenic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ERN1 protein]PMID:20399799 PMID:34801538
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