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GENE - TERM ANNOTATION REPORT

RGD ID: 1553692
Species: Mus musculus
RGD Object: Gene
Symbol: Snai1
Name: snail family zinc finger 1
Acc ID: DOID:0050827
Term: rheumatic heart disease
Definition: A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Rheumatic_heart_disease "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Snai1 ISOSnai1 (Rattus norvegicus)155882558RGDmRNA, protein:increases expression:mitral valve, heart (rat) 
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