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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551095
Species: Mus musculus
RGD Object: Gene
Symbol: Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Reladecreases phosphorylationEXP 6480464CTDAcetylcysteine results in decreased phosphorylation of RELA proteinPMID:36786954
Relamultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA mRNA]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [[PRKAA2 protein affects the susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [endotoxin, Escherichia coli affects the localization of and results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [JP8 aviation fuel results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA mRNA]; Acetylcysteine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; Acetylcysteine promotes the reaction [Particulate Matter results in decreased phosphorylation of RELA protein]PMID:19095747 PMID:19608869 PMID:23755222 PMID:29329563 PMID:29753072 PMID:36343683 PMID:36786954 PMID:36880428 PMID:37369159 PMID:37598416 PMID:39260547
Reladecreases phosphorylationISORela (Rattus norvegicus)6480464CTDAcetylcysteine results in decreased phosphorylation of RELA proteinPMID:29087013
Relaincreases activityISORELA (Homo sapiens)6480464CTDAcetylcysteine results in increased activity of RELA proteinPMID:7491977
Relaincreases glutathionylationISORELA (Homo sapiens)6480464CTDAcetylcysteine results in increased glutathionylation of RELA proteinPMID:20116392 PMID:20351055
Relaincreases phosphorylationISORELA (Homo sapiens)6480464CTDAcetylcysteine results in increased phosphorylation of RELA proteinPMID:36646296
Relamultiple interactionsISORELA (Homo sapiens)6480464CTD[Acetylcysteine co-treated with oenothein B] results in decreased phosphorylation of RELA protein; [Acetylcysteine co-treated with TNF protein] results in decreased activity of RELA protein; Acetylcysteine affects the localization of and results in increased activity of RELA protein; Acetylcysteine affects the reaction [[manganese chloride results in increased abundance of Manganese] which affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione results in decreased expression of RELA protein]; Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]; Acetylcysteine inhibits the reaction [Acrolein results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [APP protein affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Chloroquine results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [chrysin results in increased activity of RELA protein]; Acetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [cryptotanshinone affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Fenbendazole analog results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Fenbendazole results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein]; Acetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; Acetylcysteine inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; Acetylcysteine inhibits the reaction [Imatinib Mesylate results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased phosphorylation of RELA protein]]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [Nicotine results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [ovatodiolide results in decreased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Particulate Matter affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [saikosaponin D results in increased acetylation of RELA protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of RELA protein modified form]; Acetylcysteine inhibits the reaction [tert-butyl-2-(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2-pyrrolidine-1-carboxylic ester) affects the expression of RELA protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [TNF protein results in increased activity of RELA protein]PMID:15139008 PMID:17925309 PMID:18457675 PMID:19176594 PMID:19281832 PMID:21533553 PMID:21741372 PMID:22704995 PMID:23114885 PMID:24961358 PMID:25876056 PMID:25972196 PMID:27235710 PMID:27393034 PMID:28004443 PMID:28115242 PMID:28495310 PMID:28600121 PMID:29329563 PMID:30452899 PMID:31068539 PMID:32687961 PMID:34171359 PMID:34310962 PMID:34510229 PMID:34890707 PMID:35122928 PMID:35190838 PMID:35349355 PMID:35569513 PMID:36055550 PMID:36646296 PMID:37393521 PMID:39276908 PMID:8760145
Relamultiple interactionsISORela (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [7-ketocholesterol results in increased expression of and results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of and affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of RELA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of RELA protein modified form]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of RELA protein]; Acetylcysteine inhibits the reaction [RELA protein binds to MMP9 promoter]; Acetylcysteine inhibits the reaction [Smoke affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [TNF protein affects the localization of RELA protein]PMID:11970852 PMID:19760616 PMID:22664789 PMID:23774252 PMID:25845326 PMID:28583816 PMID:29087013 PMID:29426002 PMID:35285579
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