GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Kras | decreases response to substance | ISO | KRAS (Homo sapiens) | 6480464 | CTD | KRAS protein mutant form results in decreased susceptibility to temsirolimus | PMID:24493623 | Kras | multiple interactions | ISO | KRAS (Homo sapiens) | 6480464 | CTD | KRAS protein mutant form inhibits the reaction [temsirolimus inhibits the reaction [CIP2A protein binds to MTOR protein]]; KRAS protein mutant form inhibits the reaction [temsirolimus results in decreased expression of MTOR protein]; KRAS protein mutant form inhibits the reaction [temsirolimus results in decreased phosphorylation of MAPK1 protein]; KRAS protein mutant form inhibits the reaction [temsirolimus results in decreased phosphorylation of MAPK3 protein] | PMID:24493623 | |
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