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GENE - TERM ANNOTATION REPORT

RGD ID: 14256575
Species: Sus scrofa
RGD Object: Gene
Symbol: JAK3
Name: Janus kinase 3
Acc ID: GO:0060397
Term: growth hormone receptor signaling pathway via JAK-STAT
Definition: The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
Definition Source(s): GOC:BHF, GOC:dph, PMID:11445442
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JAK3involved_inIBAMGI:96629 or PANTHER:PTN002521566 or Jak2 (Rattus norvegicus)150520179GO_Central GO_REF:0000033
JAK3involved_inIEAPANTHER:PTHR45807:SF3150520179TreeGrafter GO_REF:0000118
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