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GENE - TERM ANNOTATION REPORT

RGD ID: 14256575
Species: Sus scrofa
RGD Object: Gene
Symbol: JAK3
Name: Janus kinase 3
Acc ID: GO:0007259
Term: cell surface receptor signaling pathway via JAK-STAT
Definition: A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
Definition Source(s): PMID:12039028
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JAK3involved_inIBAFB:FBgn0004864 or MGI:96628 or MGI:96629 or PANTHER:PTN001562978 or Jak2 (Rattus norvegicus) or UniProtKB:O60674 or UniProtKB:P23458 or UniProtKB:P29597 or ZFIN:ZDB-GENE-980526-481150520179GO_Central GO_REF:0000033
JAK3involved_inIEAPANTHER:PTHR45807:SF3150520179TreeGrafter GO_REF:0000118
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