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GENE - TERM ANNOTATION REPORT

RGD ID: 14131810
Species: Sus scrofa
RGD Object: Gene
Symbol: IGF1R
Name: insulin like growth factor 1 receptor
Acc ID: PW:0000238
Term: insulin-like growth factor signaling pathway
Definition: Insulin-like growth factor signaling plays important roles in cell growth and proliferation. Produced primarily by the liver in response to stimulation by growth hormone (GH), the proteins activate cognate receptors to prompt intracellular signaling pathways and cell growth in a variety of tissues. Deregulation of the pathway has been associated with various conditions, including cancer.
Definition Source(s): GO:0048009, PID:200100, PMID:12169433
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1R ISOIgf1r (Rattus norvegicus)9068941RGD PMID:15272025 PMID:20042609 REF_RGD_ID:1581313 REF_RGD_ID:7242068
IGF1R ISOIGF1R (Homo sapiens)9068941RGD PMID:15862547 REF_RGD_ID:1626333
IGF1R ISOIGF1R (Homo sapiens)9068941PID PID:200100
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