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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359573
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xrcc4
Name: X-ray repair cross complementing 4
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xrcc4decreases response to substanceISOXRCC4 (Homo sapiens)6480464CTDXRCC4 results in decreased susceptibility to EtoposidePMID:21785230
Xrcc4increases expressionISOXRCC4 (Homo sapiens)6480464CTDEtoposide results in increased expression of XRCC4 proteinPMID:16417649
Xrcc4multiple interactionsISOXRCC4 (Homo sapiens)6480464CTDBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC4 protein]PMID:16417649
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