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Gene: XRCC4 (X-ray repair cross complementing 4) Homo sapiens
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Symbol: XRCC4
Name: X-ray repair cross complementing 4
Description: Exhibits identical protein binding activity and protein C-terminus binding activity. Involved in DNA repair; positive regulation of ligase activity; and response to X-ray. Localizes to the cytosol and nucleus. Implicated in multiple myeloma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross-complementing protein 4; X-ray repair, complementing defective, repair in Chinese hamster
Orthologs:
Mus musculus (house mouse) : Xrcc4 (X-ray repair complementing defective repair in Chinese hamster cells 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xrcc4 (X-ray repair cross complementing 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrcc4 (X-ray repair cross complementing 4)
Pan paniscus (bonobo/pygmy chimpanzee) : XRCC4 (X-ray repair cross complementing 4)
Canis lupus familiaris (dog) : XRCC4 (X-ray repair cross complementing 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrcc4 (X-ray repair cross complementing 4)
Sus scrofa (pig) : XRCC4 (X-ray repair cross complementing 4)
Chlorocebus sabaeus (green monkey) : XRCC4 (X-ray repair cross complementing 4)
Heterocephalus glaber (naked mole-rat) : Xrcc4 (X-ray repair cross complementing 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl583,077,498 - 83,353,787 (+)Ensembl
GRCh38583,077,409 - 83,370,333 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37582,373,317 - 82,649,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36582,409,073 - 82,685,335 (+)NCBINCBI36hg18NCBI36
Build 34582,409,072 - 82,685,333NCBI
Celera578,277,921 - 78,554,649 (+)NCBI
Cytogenetic Map5q14.2NCBI
HuRef577,581,701 - 77,857,876 (+)NCBIHuRef
CHM1_1581,806,136 - 82,082,296 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on XRCC4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353234
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.