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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353911
Species: Homo sapiens
RGD Object: Gene
Symbol: OGG1
Name: 8-oxoguanine DNA glycosylase
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OGG1affects expressionEXP 6480464CTDArsenic affects the expression of OGG1PMID:21235219
OGG1decreases expressionEXP 6480464CTDArsenic results in decreased expression of OGG1 mRNA; Arsenic results in decreased expression of OGG1 proteinPMID:20478284 PMID:35490796 PMID:36178927
OGG1increases expressionEXP 6480464CTDArsenic results in increased expression of OGG1 mRNA; Arsenic results in increased expression of OGG1 proteinPMID:16759981 PMID:21332098
OGG1multiple interactionsEXP 6480464CTD[Selenium co-treated with Arsenic] results in increased expression of OGG1 protein; Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 mRNA]; Curcumin inhibits the reaction [Arsenic results in increased expression of OGG1 protein]; Folic Acid inhibits the reaction [Arsenic results in decreased expression of OGG1 mRNA]PMID:20478284 PMID:21332098 PMID:35490796
OGG1increases expressionISOOgg1 (Mus musculus)6480464CTDArsenic results in increased expression of OGG1 mRNAPMID:22641096
OGG1multiple interactionsISOOgg1 (Rattus norvegicus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of OGG1 mRNAPMID:31542844
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