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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:9986
Term: vinclozolin
Definition: A racemate comprising equimolar amounts of (R)- and (S)-vinclozolin. A fungicide used mainly on oilseed rape, vines, fruit and vegetables to control Botrytis, Sclerotinia and Monilia spp.
Chemical ID: MESH:C025643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects chemical synthesisISOCyp3a2 (Rattus norvegicus)6480464CTDCYP3A2 protein affects the chemical synthesis of vinclozolin metabolitePMID:22002493
CYP3A4increases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDvinclozolin results in increased expression of CYP3A2 proteinPMID:25929820
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