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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:9907
Term: ursodeoxycholic acid
Definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Chemical ID: MESH:D014580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of Ursodeoxycholic AcidPMID:15708356
CYP3A4increases expressionEXP 6480464CTDUrsodeoxycholic Acid results in increased expression of CYP3A4 mRNAPMID:16678547
CYP3A4increases hydroxylationEXP 6480464CTDCYP3A4 protein results in increased hydroxylation of Ursodeoxycholic AcidPMID:36473578
CYP3A4multiple interactionsEXP 6480464CTD[CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of Ursodeoxycholic AcidPMID:19487251
CYP3A4increases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDUrsodeoxycholic Acid results in increased expression of CYP3A2 mRNAPMID:19255942
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTD[CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Ursodeoxycholic Acid; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP3A2 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP3A2 mRNA]PMID:10453939 PMID:32198087 PMID:34461081
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