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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:7852
Term: oxycodone
Definition: A semisynthetic opioid of formula C18H21NO4 that is derived from thebaine. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain.
Chemical ID: MESH:D010098
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein alternative form affects the metabolism of OxycodonePMID:33393779
CYP3A4multiple interactionsEXP 6480464CTDtelithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone]PMID:19755414
CYP3A4decreases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDOxycodone results in decreased expression of CYP3A2 mRNA; Oxycodone results in decreased expression of CYP3A2 proteinPMID:20487198
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTDOxycodone inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Testosterone]PMID:20487198
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