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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:6904
Term: metoprolol
Definition: A propanolamine that is 1-(propan-2-ylamino)propan-2-ol substituted by a 4-(2-methoxyethyl)phenoxy group at position 1.
Chemical ID: MESH:D008790
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases hydroxylationEXP 6480464CTDCYP3A4 protein results in increased hydroxylation of MetoprololPMID:30087611
CYP3A4multiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol]PMID:30087611
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