GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | increases activity | EXP | | 6480464 | CTD | Flutamide results in increased activity of CYP3A4 protein | PMID:18839173 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | Flutamide results in increased expression of CYP3A4 mRNA | PMID:18839173 | CYP3A4 | increases response to substance | EXP | | 6480464 | CTD | CYP3A4 protein results in increased susceptibility to Flutamide | PMID:28762043 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Flutamide; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]] | PMID:23397584 PMID:32682830 | CYP3A4 | decreases expression | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Flutamide results in decreased expression of CYP3A2 mRNA | PMID:24136188 | CYP3A4 | increases expression | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Flutamide results in increased expression of CYP3A2 mRNA | PMID:24793618 | CYP3A4 | multiple interactions | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | [SOD2 co-treated with CYP3A4] affects the susceptibility to Flutamide | PMID:19501153 | | ||||||||||||||||||||||
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