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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects hydroxylationEXP 6480464CTDCYP3A4 protein affects the hydroxylation of Ethinyl EstradiolPMID:2271712
CYP3A4affects metabolic processingEXP 6480464CTDCYP3A4 protein affects the metabolism of Ethinyl EstradiolPMID:15286053
CYP3A4increases hydroxylationEXP 6480464CTDCYP3A4 protein results in increased hydroxylation of Ethinyl EstradiolPMID:15304426 PMID:15554232
CYP3A4multiple interactionsEXP 6480464CTD[Carbamazepine results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol; [Phenobarbital results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol; [pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol; [Rifampin results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol; [troglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol; Ethinyl Estradiol binds to and results in decreased activity of CYP3A4 protein; Ethinyl Estradiol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Testosterone inhibits the reaction [Ethinyl Estradiol results in decreased activity of CYP3A4 protein]PMID:11907170 PMID:19299527 PMID:22524704
CYP3A4decreases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDEthinyl Estradiol results in decreased expression of CYP3A2 mRNAPMID:15953391
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