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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases expressionEXP 6480464CTDsulforaphane results in decreased expression of CYP3A4 mRNAPMID:20442190 PMID:26775663
CYP3A4multiple interactionsEXP 6480464CTDsulforaphane inhibits the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA]; sulforaphane inhibits the reaction [Rifampin results in increased expression of CYP3A4]PMID:23153560 PMID:26775663
CYP3A4decreases activityISOCyp3a2 (Rattus norvegicus)6480464CTDsulforaphane results in decreased activity of CYP3A2 proteinPMID:22664424
CYP3A4increases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDsulforaphane results in increased expression of CYP3A2 proteinPMID:18823965
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTDsulforaphane results in decreased expression of and results in decreased activity of CYP3A2 proteinPMID:15906351
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