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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:4659
Term: disulfiram
Definition: An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.
Chemical ID: MESH:D004221
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases response to substanceEXP 6480464CTDCYP3A4 protein results in increased susceptibility to DisulfiramPMID:21540358
CYP3A4decreases activityISOCyp3a2 (Rattus norvegicus)6480464CTDDisulfiram results in decreased activity of CYP3A2 proteinPMID:9393675
CYP3A4decreases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDDisulfiram results in decreased expression of CYP3A2 mRNAPMID:9393675
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