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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of CYP3A4 mRNA; Acetaminophen results in decreased expression of CYP3A4 proteinPMID:29067470 PMID:32112222
CYP3A4increases expressionEXP 6480464CTDAcetaminophen results in increased expression of CYP3A4 mRNAPMID:26497421 PMID:30008028
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of Acetaminophen; CYP3A4 results in increased metabolism of AcetaminophenPMID:19460945 PMID:20566340 PMID:33259822
CYP3A4increases response to substanceEXP 6480464CTDCYP3A4 protein results in increased susceptibility to AcetaminophenPMID:26706816 PMID:26718876 PMID:27485346
CYP3A4multiple interactionsEXP 6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of CYP3A4 mRNA; Acetaminophen results in decreased degradation of and results in increased activity of CYP3A4 protein; CYP3A4 protein promotes the reaction [Acetaminophen results in decreased abundance of Glutathione]; NR1I2 protein affects the reaction [CYP3A4 protein results in increased metabolism of Acetaminophen]PMID:11811955 PMID:19460945 PMID:27485346 PMID:33819548
CYP3A4decreases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDAcetaminophen results in decreased expression of CYP3A2 mRNAPMID:17126469 PMID:21807079 PMID:30723492
CYP3A4increases activityISOCyp3a2 (Rattus norvegicus)6480464CTDAcetaminophen results in increased activity of CYP3A4 proteinPMID:19932728
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTD[Acetaminophen co-treated with Uranium analog] results in decreased expression of CYP3A2 mRNA; Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP3A4 protein]PMID:17126469 PMID:19932728
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