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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:4035
Term: cyhalothrin
Definition: A carboxylic ester obtained by formal condensation between 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C037304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityEXP 6480464CTDcyhalothrin results in decreased activity of CYP3A4 proteinPMID:20183062
CYP3A4increases activityEXP 6480464CTDcyhalothrin results in increased activity of CYP3A4 proteinPMID:22310298
CYP3A4increases expressionEXP 6480464CTDcyhalothrin results in increased expression of CYP3A4 mRNA; cyhalothrin results in increased expression of CYP3A4 proteinPMID:19249324 PMID:22310298
CYP3A4multiple interactionsEXP 6480464CTD[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNAPMID:25028461
CYP3A4increases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDcyhalothrin results in increased expression of CYP3A2 mRNAPMID:29727961
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