GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | increases activity | EXP | | 6480464 | CTD | Clofibric Acid results in increased activity of CYP3A4 protein | PMID:15771232 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | Clofibric Acid results in increased expression of CYP3A4 mRNA | PMID:15771232 | CYP3A4 | increases expression | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Clofibric Acid results in increased expression of CYP3A2 mRNA | PMID:15788368 | CYP3A4 | multiple interactions | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; Clofibric Acid results in increased expression of and results in increased activity of CYP3A2 protein | PMID:15788368 | | ||||||||||||||||||||||
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