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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityISOCyp3a2 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased activity of CYP3A2 proteinPMID:14706259
CYP3A4decreases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased expression of CYP3A2 mRNA; Carbon Tetrachloride results in decreased expression of CYP3A2 protein; Carbon Tetrachloride results in decreased expression of CYP3A4 mRNAPMID:10445401 PMID:14706259 PMID:17606319 PMID:19224547 PMID:30723492
CYP3A4increases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of CYP3A2 mRNAPMID:31150632
CYP3A4increases metabolic processingISOCyp3a2 (Rattus norvegicus)6480464CTDCYP3A2 protein results in increased metabolism of Carbon TetrachloridePMID:15988118
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