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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:18358
Term: methoxsalen
Definition: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Chemical ID: MESH:D008730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityEXP 6480464CTDMethoxsalen results in decreased activity of CYP3A4 proteinPMID:18420780
CYP3A4increases expressionEXP 6480464CTDMethoxsalen results in increased expression of CYP3A4 mRNA; Methoxsalen results in increased expression of CYP3A4 proteinPMID:17003103
CYP3A4multiple interactionsEXP 6480464CTDDichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]; NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA]PMID:17003103
CYP3A4decreases activityISOCyp3a2 (Rattus norvegicus)6480464CTDMethoxsalen results in decreased activity of CYP3A2 proteinPMID:15879494
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