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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:17578
Term: toluene
Definition: The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent.
Chemical ID: MESH:D014050
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDToluene results in increased expression of CYP3A2 mRNAPMID:17209515
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTD1-Butanol promotes the reaction [Toluene results in increased expression of CYP3A2 mRNA]PMID:17209515
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