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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of CYP3A4 mRNAPMID:27551952
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalatePMID:22186153 PMID:23545481
CYP3A4multiple interactionsEXP 6480464CTD[CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate; [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate; [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid; [Dexamethasone co-treated with mono-(2-ethylhexyl)phthalate] results in increased activity of CYP3A4 proteinPMID:18332045 PMID:22186153 PMID:23545481
CYP3A4increases metabolic processingISOCyp3a2 (Rattus norvegicus)6480464CTDCYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalatePMID:22186153 PMID:23545481
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTD[CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate; [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate; [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acidPMID:22186153 PMID:23545481
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