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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4affects bindingEXP 6480464CTDEstradiol binds to CYP3A4 proteinPMID:9047321
CYP3A4affects hydroxylationEXP 6480464CTDCYP3A4 protein affects the hydroxylation of EstradiolPMID:2271712
CYP3A4increases expressionEXP 6480464CTDEstradiol results in increased expression of CYP3A4 mRNA; Estradiol results in increased expression of CYP3A4 proteinPMID:12505310 PMID:15650019 PMID:22837389 PMID:35747940
CYP3A4increases hydroxylationEXP 6480464CTDCYP3A4 protein results in increased hydroxylation of EstradiolPMID:9047321 PMID:9714305
CYP3A4increases metabolic processingEXP 6480464CTDCYP3A4 protein results in increased metabolism of EstradiolPMID:16790556
CYP3A4multiple interactionsEXP 6480464CTD[Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CYP3A4 mRNA; Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol]; CYP3A4 promoter mutant form inhibits the reaction [Estradiol results in increased expression of CYP3A4 mRNA]; decamethrin inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol]; Fonofos inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol]; Permethrin inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol]PMID:12505310 PMID:16790556 PMID:35747940
CYP3A4affects expressionISOCyp3a2 (Rattus norvegicus)6480464CTDEstradiol affects the expression of CYP3A2 mRNAPMID:32145629
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