GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | affects metabolic processing | EXP | | 6480464 | CTD | CYP3A4 protein affects the metabolism of Lithocholic Acid | PMID:15708356 | CYP3A4 | increases activity | EXP | | 6480464 | CTD | Lithocholic Acid results in increased activity of CYP3A4 protein mutant form | PMID:19299527 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | Lithocholic Acid results in increased expression of CYP3A4 mRNA | PMID:17965521 PMID:18645036 PMID:19562681 PMID:20888898 | CYP3A4 | increases hydroxylation | EXP | | 6480464 | CTD | CYP3A4 protein results in increased hydroxylation of Lithocholic Acid | PMID:36473578 | CYP3A4 | increases metabolic processing | EXP | | 6480464 | CTD | CYP3A4 protein results in increased metabolism of Lithocholic Acid | PMID:19487251 | CYP3A4 | increases oxidation | EXP | | 6480464 | CTD | CYP3A4 protein results in increased oxidation of Lithocholic Acid | PMID:31102695 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [CYP3A4 protein results in increased hydroxylation of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid; [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of 3-ketocholanoic acid; [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid; [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of Ursodeoxycholic Acid; [CYP3A4 protein results in increased oxidation of Lithocholic Acid] which results in increased chemical synthesis of 3-ketocholanoic acid; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Lithocholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; tocotrienol, alpha inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, delta inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Tocotrienols inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA] | PMID:15489543 PMID:15578590 PMID:18645036 PMID:19299527 PMID:19487251 PMID:31102695 PMID:36473578 | CYP3A4 | decreases activity | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Lithocholic Acid results in decreased activity of CYP3A2 protein | PMID:8889968 | CYP3A4 | increases expression | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Lithocholic Acid results in increased expression of CYP3A2 mRNA | PMID:20006981 PMID:20888898 | CYP3A4 | increases metabolic processing | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | CYP3A2 protein results in increased metabolism of Lithocholic Acid | PMID:18039809 | CYP3A4 | multiple interactions | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | [CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid; [CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog; [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] affects the abundance of Lithocholic Acid | PMID:18039809 PMID:34461081 | | ||||||||||||||||||||||
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