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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases expressionEXP 6480464CTDEthanol results in increased expression of CYP3A4 mRNA; Ethanol results in increased expression of CYP3A4 proteinPMID:28062356 PMID:35301062
CYP3A4decreases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDEthanol results in decreased expression of CYP3A2 mRNAPMID:26109895
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