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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350750
Species: Homo sapiens
RGD Object: Gene
Symbol: SLCO1B3
Name: solute carrier organic anion transporter family member 1B3
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLCO1B3decreases expressionISOSlco1b2 (Rattus norvegicus)6480464CTD1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA; 1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 proteinPMID:17522070 PMID:27317372
SLCO1B3decreases expressionISOSlco1b2 (Mus musculus)6480464CTD1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNAPMID:19181614 PMID:19407337 PMID:25655198 PMID:30517764 PMID:33749747
SLCO1B3multiple interactionsISOSlco1b2 (Rattus norvegicus)6480464CTDdioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; dioscin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 protein]PMID:27317372
SLCO1B3multiple interactionsISOSlco1b2 (Mus musculus)6480464CTD[1-Naphthylisothiocyanate co-treated with Allopurinol] results in decreased expression of SLCO1B2 mRNA; [1-Naphthylisothiocyanate co-treated with Uric Acid] results in decreased expression of SLCO1B2 mRNA; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]; NFE2L2 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLCO1B2 mRNA]PMID:19181614 PMID:30517764 PMID:33749747
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