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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348525
Species: Homo sapiens
RGD Object: Gene
Symbol: DUSP4
Name: dual specificity phosphatase 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DUSP4increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of DUSP4 mRNAPMID:17101203 PMID:19619570
DUSP4multiple interactionsEXP 6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP4 mRNAPMID:19619570
DUSP4affects expressionISODusp4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of DUSP4 mRNAPMID:21570461 PMID:24680724
DUSP4decreases expressionISODusp4 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of DUSP4 mRNAPMID:33387578 PMID:34747641
DUSP4increases expressionISODusp4 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of DUSP4 mRNAPMID:32109520
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