A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID:
MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
4-phenylbutyric acid inhibits the reaction [Rotenone results in increased expression of PARK7 protein]; [BAG5 protein binds to and results in increased degradation of PARK7 protein] which results in increased susceptibility to Rotenone; Acetylcysteine inhibits the reaction [Rotenone results in increased expression of PARK7 protein]; alpha-Tocopherol inhibits the reaction [Rotenone affects the localization of PARK7 protein]; BAG5 protein inhibits the reaction [PARK7 protein results in decreased susceptibility to Rotenone]; BAG5 protein inhibits the reaction [Rotenone affects the localization of PARK7 protein]; Bibenzyls inhibits the reaction [Rotenone results in decreased expression of PARK7 protein]; PARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]; PARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]; PARK7 protein affects the reaction [Bibenzyls promotes the reaction [Rotenone affects the localization of NFE2L2 protein]]; PARK7 protein inhibits the reaction [Rotenone results in decreased expression of NDUFS3 protein]; PARK7 protein inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein]; PARK7 protein inhibits the reaction [Rotenone results in increased expression of CD68 protein]; PARK7 protein inhibits the reaction [Rotenone results in increased expression of LAMP2 protein alternative form]; PARK7 protein inhibits the reaction [Rotenone results in increased expression of NOS2 protein]; polydatin inhibits the reaction [Rotenone results in increased expression of PARK7 protein]
Bibenzyls inhibits the reaction [Rotenone results in decreased expression of PARK7 protein]; PARK7 protein affects the reaction [[Rotenone co-treated with Bibenzyls] affects the localization of NFE2L2 protein]; PARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein]]; PARK7 protein affects the reaction [Bibenzyls inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein]]
