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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344001
Species: Homo sapiens
RGD Object: Gene
Symbol: GDF15
Name: growth differentiation factor 15
Acc ID: CHEBI:75408
Term: sulindac sulfide
Definition: An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
Chemical ID: MESH:C025462
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GDF15increases expressionEXP 6480464CTDsulindac sulfide results in increased expression of GDF15 mRNA; sulindac sulfide results in increased expression of GDF15 proteinPMID:11895857 PMID:11925476 PMID:12734198 PMID:15180942 PMID:15509713 PMID:15555568 PMID:15767558
GDF15multiple interactionsEXP 6480464CTDEGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]PMID:15509713
GDF15increases expressionISOGdf15 (Mus musculus)6480464CTDsulindac sulfide results in increased expression of GDF15 mRNAPMID:18076062
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