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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344001
Species: Homo sapiens
RGD Object: Gene
Symbol: GDF15
Name: growth differentiation factor 15
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GDF15decreases response to substanceEXP 6480464CTDGDF15 protein results in decreased susceptibility to TamoxifenPMID:22615612
GDF15affects expressionISOGdf15 (Mus musculus)6480464CTDTamoxifen affects the expression of GDF15 mRNAPMID:20937368
GDF15increases expressionISOGdf15 (Mus musculus)6480464CTDTamoxifen results in increased expression of GDF15 mRNAPMID:25123088
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