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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342784
Species: Homo sapiens
RGD Object: Gene
Symbol: DDIT4L
Name: DNA damage inducible transcript 4 like
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DDIT4Laffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of DDIT4L promoterPMID:27901495
DDIT4Lincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of DDIT4L 5' UTRPMID:27901495
DDIT4Lincreases expressionISODdit4l (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of DDIT4L mRNAPMID:21839799
DDIT4Lincreases expressionISODdit4l (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of DDIT4L mRNAPMID:15034205 PMID:19770486 PMID:21569818 PMID:21715664 PMID:21964900 PMID:22610609 PMID:23735875
DDIT4Lmultiple interactionsISODdit4l (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDIT4L mRNAPMID:27858113
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